唾液酸化综述发表

2018年11月26日本课题组关于唾液酸化修饰介导个体发育、体细胞重编程、癌症发生发展过程中细胞命运决定的综述在《Protein & Cell》上发表!


唾液酸化修饰是一种糖基化修饰,唾液酸通过共价键连接到糖蛋白糖链的末端。唾液酸具有较强的负电性,在生理状态下电离出负电荷,并且位于糖链末端,因此,唾液酸化修饰可能在生物体生理功能发挥中起重要作用。目前已报道,唾液酸化修饰在早期胚胎发育、神经发育、体细胞重编程、癌症发生发展及免疫反应中起重要作用。本文主要阐述唾液酸化修饰在个体发育、体细胞重编程、癌症发生发展过程中细胞命运决定中的作用。唾液酸化合成酶UDP-GlcNAc 2-epimerase对小鼠早期胚胎发育至关重要,编码该酶的基因Gne敲除会引起小鼠胚胎在第10.5天死亡。唾液酸化糖基转移酶基因ST6GAL1敲低降低体细胞重编程效率。另外,唾液酸化水平和糖型在癌症发生发展过程中发生变化。因此,唾液酸化修饰与细胞命运决定息息相关。

 

Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a biologically important modification that is involved in embryonic development, neurodevelopment, reprogramming, oncogenesis and immune responses. In this review, we have given a comprehensive

overview of the current literature on the involvement of sialylation in cell fate decision during

development, reprogramming and cancer progression. Sialylation is essential for early embryonic development and the deletion of UDP-GlcNAc 2-epimerase, a rate-limiting enzyme in sialic acid biosynthesis, is embryonically lethal. Furthermore, the sialyltransferase ST6GAL1 is required for somatic cell reprogramming, and its downregulation is associated with decreased reprogramming

efficiency. In addition, sialylation levels and patterns are altered during cancer progression, indicating the potential of sialylated molecules as cancer biomarkers. Taken together, the current evidences demonstrate that sialylation is involved in crucial cell fate decision.



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